IGSF8

Across TCGA cell cohorts, IGSF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,006 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGSF8-associated GO terms across cancer lineages are Cytokinesis, Glycerophospholipid metabolic process, and Actomyosin contractile ring organization. Each is linked with IGSF8 in more than 12 cancer types. Because this analysis shows association rather than direction, both IGSF8-to-partner and partner-to-IGSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytokinesis grouped by IGSF8-low versus IGSF8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF8→partner) and Y-score (partner→IGSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cytokinesis →	+0.065	+0.861	.001	.004	3	12
SKIN	Glycerophospholipid metabolic process →	+0.041	+1.811	<.001	<.001	3	12
URINARY_TRACT	Actomyosin contractile ring organization →	+0.174	+1.795	.001	.002	3	12
LUNG_NSCLC_LUSC	Regulation of protein localization to endoplasmic reticulum →	+0.119	+1.135	.003	.001	1	13
SKIN	Positive regulation of protein localization to endoplasmic reticulum →	+0.109	+1.941	.003	<.001	3	11
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.096	+1.295	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,006 associations by consensus.

Cytokinesis by IGSF8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →