IGSF8

Across TCGA cell cohorts, IGSF8 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGSF8-associated genes across cancer lineages are GHRHR, MAGEB5, and C9orf92. Each is linked with IGSF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF8-to-partner and partner-to-IGSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by IGSF8-low versus IGSF8-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF8→partner) and Y-score (partner→IGSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GHRHR →	+0.176	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Leukemia	C9orf92 →	+0.076	+4.539	<.001	.007	3	1
SKIN	CLEC10A →	+0.033	+4.273	<.001	.006	3	1
SKIN	GAST →	+0.824	+4.095	<.001	.009	3	1
SKIN	PRSS45P →	+0.017	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

GHRHR by IGSF8 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →