IGSF6

Across TCGA pan-cancer cohorts, IGSF6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGSF6 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGSF6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGSF6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where IGSF6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.990	0.648	.007	21	view →
PDAC	DFS	Quartile	III,IV	0.170	1.000	.010	11	view →
UCEC	DFS	Tertile	All	0.653	1.000	.027	4	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.829	.026	4	view →
LUAD	DFS	Quartile	All	0.996	0.900	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGSF6–HNSC (OS)

Open the HNSC breakdown →