IGSF6

Across TCGA patient cohorts, IGSF6 protein abundance is significantly associated with the RNA expression of many other genes, with 14,100 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGSF6-associated genes across cancer lineages are KLHL6, ARHGAP9, and FAM78A. Each is linked with IGSF6 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGSF6-to-partner and partner-to-IGSF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF6 versus KLHL6 in UCEC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF6→partner) and Y-score (partner→IGSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLHL6 →	+1.480	+1.318	.003	.003	3	7
UCEC	ARHGAP9 →	+1.374	+1.468	.001	.002	3	6
OV	FAM78A →	+1.258	+0.942	.005	.005	3	6
UCEC	GPR174 →	+2.280	+1.488	<.001	<.001	3	6
UCEC	SLAMF6 →	+1.846	+1.469	.001	<.001	3	6
GBM	LAIR1 →	+1.343	+0.782	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,100 associations by consensus.

IGSF6 vs KLHL6 — UCEC

Explore this scatter interactively →