IGSF6

Across TCGA patient cohorts, IGSF6 mutation is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF6-associated genes across cancer lineages are MIR342, RNU6-838P, and RNU6-1318P. Each is linked with IGSF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF6-to-partner and partner-to-IGSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR342 grouped by IGSF6-low versus IGSF6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF6→partner) and Y-score (partner→IGSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR342 →	+0.666	+4.415	<.001	.006	3	2
COAD	RNU6-838P →	+0.566	+4.516	<.001	.009	3	2
COAD	RNU6-1318P →	+1.043	+4.237	<.001	.008	3	2
UCEC	LINC02379 →	+0.238	+4.464	<.001	.005	3	2
LUAD	SYF2P1 →	+0.194	+6.315	<.001	.001	3	2
STAD	MIR3689B →	+0.332	+6.226	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

MIR342 by IGSF6 expression — COAD

Explore this box plot interactively →