IGSF6

Across TCGA patient cohorts, IGSF6 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF6-associated genes across cancer lineages are EGFR_pY1173 and YB-1. Each is linked with IGSF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF6-to-partner and partner-to-IGSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by IGSF6-low versus IGSF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF6→partner) and Y-score (partner→IGSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.121	+2.833	.013	.035	1	2
UCEC	YB-1 →	+0.236	+2.833	.015	.035	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

EGFR_pY1173 by IGSF6 expression — UCEC

Explore this box plot interactively →