IGSF6

Across TCGA cell cohorts, IGSF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,347 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGSF6-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Late viral transcription, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with IGSF6 in more than 14 cancer types. Because this analysis shows association rather than direction, both IGSF6-to-partner and partner-to-IGSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by IGSF6-low versus IGSF6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF6→partner) and Y-score (partner→IGSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of alternative mRNA splicing, via spliceosome →	+0.108	+0.295	<.001	<.001	3	15
BONE	Late viral transcription →	+0.166	+0.239	<.001	<.001	3	15
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.202	+0.286	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	mRNA 5'-splice site recognition →	+0.145	+0.252	<.001	.001	3	13
OESOPHAGUS	Protein localization to cytoplasmic stress granule →	+0.113	+0.189	.006	.003	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.138	-0.336	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,347 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by IGSF6 expression — BONE

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