IGSF22

Across TCGA patient cohorts, IGSF22 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,191 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGSF22-associated proteins across cancer lineages are SEPTIN8, SORBS1, and DOCK11. Each is linked with IGSF22 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGSF22-to-partner and partner-to-IGSF22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF22 versus SEPTIN8 in OV, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF22→partner) and Y-score (partner→IGSF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEPTIN8 →	+0.383	+0.271	<.001	<.001	3	4
UCEC	SORBS1 →	+0.599	+0.334	<.001	<.001	3	4
OV	DOCK11 →	+0.429	+0.234	.007	.004	2	5
BRCA	DPYSL3 →	+0.547	+0.591	<.001	<.001	3	4
OV	HDGFL3 →	+0.513	+0.262	.007	<.001	2	5
UCEC	HK2 →	-0.545	-0.343	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,191 associations by consensus.

IGSF22 vs SEPTIN8 — OV

Explore this scatter interactively →