IGSF22

Across TCGA patient cohorts, IGSF22 mutation is significantly associated with the RNA expression of many other genes, with 3,113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF22-associated genes across cancer lineages are RN7SL681P, MRPL49P2, and RNU6-234P. Each is linked with IGSF22 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF22-to-partner and partner-to-IGSF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL681P grouped by IGSF22-low versus IGSF22-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF22→partner) and Y-score (partner→IGSF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL681P →	+0.080	+2.127	<.001	.002	3	3
COAD	MRPL49P2 →	+0.053	+5.153	<.001	.001	3	3
LUSC	RNU6-234P →	+0.476	+5.792	<.001	.003	3	3
UCEC	RNA5SP113 →	+0.259	+2.300	<.001	.003	3	3
GBM	PPP1R26P4 →	+0.016	+4.459	.004	.005	3	2
BLCA	RNU6-1213P →	+0.301	+4.985	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,113 associations by consensus.

RN7SL681P by IGSF22 expression — SKCM

Explore this box plot interactively →