IGSF22

Across TCGA patient cohorts, IGSF22 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF22-associated genes across cancer lineages are C-Raf, JNK_pT183_Y185, and JNK2. Each is linked with IGSF22 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF22-to-partner and partner-to-IGSF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by IGSF22-low versus IGSF22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF22→partner) and Y-score (partner→IGSF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.154	+1.432	<.001	.005	3	3
UCEC	JNK_pT183_Y185 →	-0.141	-1.419	.004	.005	3	2
UCEC	JNK2 →	+0.250	+2.211	<.001	<.001	3	2
UCEC	MEK1 →	+0.369	+1.938	<.001	.001	3	2
UCEC	PCNA →	+0.157	+1.321	.013	.027	3	2
COAD	PDCD4 →	-0.527	-2.991	.015	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

C-Raf by IGSF22 expression — UCEC

Explore this box plot interactively →