IGSF22

Across TCGA cell cohorts, IGSF22 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,935 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGSF22-associated GO terms across cancer lineages are Negative regulation of autophagy, Golgi vesicle transport, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with IGSF22 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGSF22-to-partner and partner-to-IGSF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by IGSF22-low versus IGSF22-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF22→partner) and Y-score (partner→IGSF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.072	+0.254	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.060	+0.168	<.001	.002	3	10
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.091	+0.449	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of proteasomal protein catabolic process →	+0.066	+0.254	<.001	.005	2	10
UPPER_AERODIGESTIVE_TRACT	Regulation of macroautophagy →	+0.061	+0.168	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.101	+0.174	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,935 associations by consensus.

Negative regulation of autophagy by IGSF22 expression — UPPER_AERODIGESTIVE_TRACT

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