IGSF22

Across TCGA cell cohorts, IGSF22 mutation is significantly associated with the RNA expression of many other genes, with 213 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGSF22-associated genes across cancer lineages are OTOP1, C1QBP, and SSTR4. Each is linked with IGSF22 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF22-to-partner and partner-to-IGSF22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOP1 grouped by IGSF22-low versus IGSF22-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF22→partner) and Y-score (partner→IGSF22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOP1 →	+0.157	+4.087	.001	.009	3	2
LARGE_INTESTINE	C1QBP →	+0.628	+2.129	.002	.007	3	2
BLOOD_Leukemia	SSTR4 →	+0.018	+2.979	.007	.007	3	2
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
SOFT_TISSUE	KCNA5 →	+0.122	+5.369	<.001	.004	3	1
SOFT_TISSUE	PRAMEF10 →	+0.012	+4.930	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 213 associations by consensus.

OTOP1 by IGSF22 expression — URINARY_TRACT

Explore this box plot interactively →