IGSF21

Across TCGA pan-cancer cohorts, IGSF21 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGSF21’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGSF21 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IGSF21 is over-expressed in tumor.

LUAD and LSCC are the cancer types where IGSF21 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGSF21 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+1.039	<.001	9	view →
LSCC	Female	II,III,IV	+1.165	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGSF21–LUAD

Open the LUAD breakdown →