IGSF21

Across TCGA patient cohorts, IGSF21 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,193 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGSF21-associated proteins across cancer lineages are PCOLCE, TIMP2, and TIMP3. Each is linked with IGSF21 in more than 8 cancer types. Because this analysis shows association rather than direction, both IGSF21-to-partner and partner-to-IGSF21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF21 versus PCOLCE in LSCC, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF21→partner) and Y-score (partner→IGSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PCOLCE →	+0.687	+0.603	<.001	<.001	3	9
UCEC	TIMP2 →	+0.627	+0.404	<.001	.003	3	8
BRCA	TIMP3 →	+0.839	+1.440	<.001	<.001	3	8
OV	PDLIM4 →	+0.665	+0.646	<.001	<.001	3	8
OV	PLS3 →	+0.746	+0.547	.003	.006	3	8
UCEC	PRKG1 →	+0.539	+0.283	.003	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,193 associations by consensus.

IGSF21 vs PCOLCE — LSCC

Explore this scatter interactively →