IGSF21

Across TCGA patient cohorts, IGSF21 mutation is significantly associated with the RNA expression of many other genes, with 1,518 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGSF21-associated genes across cancer lineages are TSPY26P, GNRH1, and MIR4716. Each is linked with IGSF21 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF21-to-partner and partner-to-IGSF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY26P grouped by IGSF21-low versus IGSF21-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF21→partner) and Y-score (partner→IGSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TSPY26P →	-0.664	-1.511	<.001	.003	3	3
SKCM	GNRH1 →	+0.336	+1.739	.003	.005	3	3
HNSC	MIR4716 →	+0.302	+5.936	<.001	.001	3	3
UCEC	PLA2G4F →	-0.700	-2.967	.001	.001	3	3
SKCM	RNU6-1318P →	+0.070	+1.777	.004	.004	3	3
SKCM	MAPKAPK5-AS1 →	+0.242	+1.256	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,518 associations by consensus.

TSPY26P by IGSF21 expression — SKCM

Explore this box plot interactively →