IGSF21

Across TCGA patient cohorts, IGSF21 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF21-associated genes across cancer lineages are ACC1, Acetyl-a-Tubulin-Lys40, and p62 Lck ligand. Each is linked with IGSF21 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGSF21-to-partner and partner-to-IGSF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by IGSF21-low versus IGSF21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF21→partner) and Y-score (partner→IGSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.260	+3.335	.030	.005	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.356	+1.495	.033	.034	3	2
UCEC	p62 Lck ligand →	+0.277	+2.817	.009	.001	3	2
UCEC	XBP1 →	-0.128	-1.794	.006	.024	3	2
COAD	cIAP →	+0.148	+3.381	.013	.004	1	4
UCEC	c-Kit →	-0.162	-1.986	.035	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ACC1 by IGSF21 expression — UCEC

Explore this box plot interactively →