IGSF21

Across TCGA cell cohorts, IGSF21 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,476 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IGSF21-associated GO terms across cancer lineages are Regulation of fibrinolysis, Chromosomal 5-methylcytosine DNA demethylation pathway, and Regulation of plasminogen activation. Each is linked with IGSF21 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGSF21-to-partner and partner-to-IGSF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fibrinolysis grouped by IGSF21-low versus IGSF21-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF21→partner) and Y-score (partner→IGSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of fibrinolysis →	-0.533	-1.903	<.001	<.001	3	5
SOFT_TISSUE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.114	+1.221	<.001	.004	3	5
BONE	Regulation of plasminogen activation →	-0.358	-2.397	<.001	<.001	3	5
BONE	Positive regulation of T cell tolerance induction →	-1.660	-2.203	<.001	.002	3	5
BONE	Blood vessel morphogenesis →	-0.110	-1.992	<.001	<.001	3	5
BONE	Regulation of muscle adaptation →	-0.089	-1.704	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,476 associations by consensus.

Regulation of fibrinolysis by IGSF21 expression — BONE

Explore this box plot interactively →