IGSF21

Across TCGA cell cohorts, IGSF21 mutation is significantly associated with the RNA expression of many other genes, with 619 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGSF21-associated genes across cancer lineages are OR2L8, SPHKAP, and AWAT2. Each is linked with IGSF21 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF21-to-partner and partner-to-IGSF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by IGSF21-low versus IGSF21-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF21→partner) and Y-score (partner→IGSF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L8 →	+0.007	+3.681	<.001	.009	3	2
LARGE_INTESTINE	SPHKAP →	+0.004	+2.830	<.001	.004	3	2
LUNG_SCLC	AWAT2 →	+0.111	+3.070	.004	.009	3	1
LUNG_SCLC	BPIFB4 →	+0.430	+3.946	.001	.002	3	1
BLOOD_Lymphoma	BANF2 →	+0.096	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	CCL21 →	+0.176	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 619 associations by consensus.

OR2L8 by IGSF21 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →