IGSF21-AS1

Across TCGA pan-cancer cohorts, IGSF21-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGSF21-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGSF21-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGSF21-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LGG show a favorable association.

UCEC, ACC, and SKCM are the cancer types where IGSF21-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.585	0.845	<.001	102	view →
ACC	DFS	Tertile	All	0.046	0.753	<.001	90	view →
SKCM	DFS	Tertile	All	0.016	0.758	<.001	54	view →
READ	DFS	Tertile	All	0.235	0.703	.003	36	view →
LUSC	OS	Tertile	All	0.159	0.415	.006	36	view →
UVM	DFS	Tertile	All	0.203	0.773	.003	36	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.390	.011	27	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
KIRC	DFS	Tertile	III,IV	0.284	0.653	.013	24	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	21	view →
TGCT	OS	Tertile	All	0.872	0.976	.006	18	view →
THYM	DFS	Tertile	III,IV	0.205	0.772	.032	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGSF21-AS1–UCEC (DFS)

Open the UCEC breakdown →