IGSF11

Across TCGA cell cohorts, IGSF11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,884 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IGSF11-associated GO terms across cancer lineages are Chromosomal 5-methylcytosine DNA demethylation pathway, Regulation of syncytium formation by plasma membrane fusion, and mRNA 3'-end processing. Each is linked with IGSF11 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGSF11-to-partner and partner-to-IGSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosomal 5-methylcytosine DNA demethylation pathway grouped by IGSF11-low versus IGSF11-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF11→partner) and Y-score (partner→IGSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.162	+0.536	.002	.008	3	10
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.128	+0.919	<.001	.004	3	9
BLOOD_Leukemia	mRNA 3'-end processing →	+0.057	+0.577	<.001	.009	3	9
OESOPHAGUS	Regulation of RNA stability →	+0.050	+1.211	.006	.003	2	10
OESOPHAGUS	Positive regulation of long-term synaptic potentiation →	-0.152	-1.403	.001	<.001	3	9
STOMACH	Regulation of myoblast fusion →	+0.128	+0.690	<.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,884 associations by consensus.

Chromosomal 5-methylcytosine DNA demethylation pathway by IGSF11 expression — STOMACH

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