IGSF11

Across TCGA cell cohorts, IGSF11 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IGSF11-associated genes across cancer lineages are KRTAP4-3, CST2, and OR4A47. Each is linked with IGSF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF11-to-partner and partner-to-IGSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-3 grouped by IGSF11-low versus IGSF11-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF11→partner) and Y-score (partner→IGSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP4-3 →	+0.071	+4.930	<.001	.008	3	1
LUNG_SCLC	CST2 →	+0.056	+4.817	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR4A47 →	+0.018	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2L8 →	+0.020	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.060	+3.793	<.001	.007	3	1
SKIN	HMHB1 →	+0.076	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KRTAP4-3 by IGSF11 expression — SOFT_TISSUE

Explore this box plot interactively →