IGSF10

Across TCGA patient cohorts, IGSF10 mutation is significantly associated with the RNA expression of many other genes, with 6,246 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF10-associated genes across cancer lineages are CDKN3, CEP76, and XPNPEP1. Each is linked with IGSF10 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGSF10-to-partner and partner-to-IGSF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by IGSF10-low versus IGSF10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF10→partner) and Y-score (partner→IGSF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDKN3 →	+0.550	+1.332	<.001	<.001	3	5
COAD	CEP76 →	+0.418	+2.274	<.001	.001	3	5
BRCA	XPNPEP1 →	+0.473	+3.375	.003	.005	2	6
COAD	PPP1R8 →	+0.260	+2.550	.004	.009	3	5
COAD	SEH1L →	+0.366	+2.372	.002	.002	3	5
STAD	CEP55 →	+0.783	+3.459	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,246 associations by consensus.

CDKN3 by IGSF10 expression — UCEC

Explore this box plot interactively →