IGSF10

Across TCGA patient cohorts, IGSF10 mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF10-associated genes across cancer lineages are 4E-BP1, eEF2, and PDCD4. Each is linked with IGSF10 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGSF10-to-partner and partner-to-IGSF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by IGSF10-low versus IGSF10-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF10→partner) and Y-score (partner→IGSF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.317	+1.807	.004	.025	3	6
BRCA	eEF2 →	+0.320	+3.000	.019	.038	3	4
STAD	PDCD4 →	-0.458	-1.807	.005	.025	3	4
UCEC	Cyclin-B1 →	+0.500	+2.137	<.001	<.001	3	4
LUAD	PAI-1 →	+0.972	+3.700	.001	.001	3	4
LUAD	STAT3_pY705 →	-0.271	-3.169	.023	.018	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

4E-BP1 by IGSF10 expression — STAD

Explore this box plot interactively →