IGSF1

Across TCGA pan-cancer cohorts, IGSF1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated IGSF1 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGSF1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated IGSF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, BRCA, and SARC are the cancer types where IGSF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.817	0.620	.002	36	view →
BRCA	OS	Median	III,IV	0.314	0.834	.006	16	view →
SARC	OS	Median	All	0.177	0.842	<.001	15	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	15	view →
KIRC	OS	Median	II,III,IV	0.172	0.696	.030	12	view →
SKCM	OS	Median	III,IV	0.924	0.767	.013	7	view →
LIHC	DFS	Median	All	0.145	0.555	.021	6	view →
READ	OS	Median	III,IV	0.328	0.750	.012	4	view →
SCLC	DFS	Median	III,IV	0.137	0.517	.042	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUAD	DFS	Median	All	0.553	0.775	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGSF1–UCEC (DFS)

Open the UCEC breakdown →