IGLVV-58

Across TCGA pan-cancer cohorts, IGLVV-58 RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated IGLVV-58 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher IGLVV-58 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLVV-58 expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

UVM, UCS, and PAAD are the cancer types where IGLVV-58 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
UCS	OS	Tertile	All	0.285	0.607	.033	36	view →
PAAD	OS	Tertile	II,III,IV	0.888	0.360	.038	9	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
SKCM	DFS	Tertile	II,III,IV	0.584	0.243	.024	9	view →
ESCA	OS	Tertile	III,IV	0.867	0.376	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGLVV-58–UVM (OS)

Open the UVM breakdown →