IGLVI-63

Across TCGA pan-cancer cohorts, IGLVI-63 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGLVI-63 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLVI-63 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLVI-63 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and STAD are the cancer types where IGLVI-63 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.806	0.649	<.001	132	view →
UVM	DFS	Tertile	All	0.145	0.776	<.001	90	view →
STAD	OS	Median	All	0.329	0.489	.002	50	view →
SKCM	DFS	Median	III,IV	0.717	0.548	.004	27	view →
ESCA	DFS	Tertile	II,III,IV	0.642	0.466	.024	20	view →
KIRP	DFS	Tertile	All	0.517	0.832	.008	12	view →
MESO	OS	Quartile	III,IV	0.754	0.489	.008	10	view →
BRCA	OS	Tertile	All	0.949	0.911	.012	9	view →
THCA	OS	Tertile	IV	0.813	1.000	.039	9	view →
READ	OS	Tertile	II,III,IV	0.528	0.729	.025	7	view →
LUSC	OS	Tertile	II,III,IV	0.648	0.778	.020	6	view →
CESC	OS	Quartile	All	0.873	0.758	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGLVI-63–HNSC (DFS)

Open the HNSC breakdown →