IGLVI-38

Across TCGA pan-cancer cohorts, IGLVI-38 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGLVI-38 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher IGLVI-38 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLVI-38 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LGG show a favorable association.

MESO, TGCT, and KIRP are the cancer types where IGLVI-38 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.052	0.567	<.001	72	view →
TGCT	OS	Tertile	II,III,IV	0.501	0.996	<.001	66	view →
KIRP	OS	Tertile	III,IV	0.111	0.697	<.001	36	view →
UCEC	DFS	Tertile	III,IV	1.000	0.772	.011	36	view →
HNSC	OS	Tertile	IV	0.192	0.649	.012	30	view →
THCA	OS	Tertile	II,III,IV	0.782	0.967	<.001	27	view →
LGG	DFS	Tertile	All	0.913	0.785	.001	22	view →
LUSC	OS	Tertile	All	0.427	0.670	.008	18	view →
LIHC	DFS	Tertile	All	0.100	0.526	.038	18	view →
SKCM	OS	Tertile	IV	0.167	0.657	.003	9	view →
ACC	DFS	Tertile	All	0.195	0.748	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGLVI-38–MESO (OS)

Open the MESO breakdown →