Across TCGA pan-cancer cohorts, IGLV9-49 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGLV9-49 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV9-49 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGLV9-49 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where IGLV9-49 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.936	0.701	.012	24	view →
PDAC	OS	Median	All	0.470	0.710	.004	22	view →
LSCC	DFS	Median	II,III,IV	0.528	0.823	.008	10	view →
CCRCC	OS	Tertile	All	0.933	0.757	.034	6	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.330	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV9-49 tumor-vs-normal RNA expression · all IGLV9-49 data types