Across TCGA pan-cancer cohorts, IGLV8OR8-1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGLV8OR8-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGLV8OR8-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV8OR8-1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGLV8OR8-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV8OR8-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.750	<.001	10	view →
LUAD	All	All	+0.232	.020	1	view →
KIRC	All	All	+0.114	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGLV8OR8-1 RNA expression & survival · all IGLV8OR8-1 data types