Across TCGA pan-cancer cohorts, IGLV7-46 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGLV7-46 data layer compared with 18 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IGLV7-46 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGLV7-46 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where IGLV7-46 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.906	.016	10	view →
HNSC	DFS	Median	III,IV	1.000	0.899	.019	5	view →
GBM	DFS	Median	All	0.441	0.266	.005	3	view →
LSCC	OS	Tertile	III,IV	1.000	0.597	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGLV7-46 tumor-vs-normal RNA expression · all IGLV7-46 data types