Across TCGA patient cohorts, IGLV7-46 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGLV7-46-associated genes across cancer lineages are MTATP6P21, MIR5088, and LINC02862. Each is linked with IGLV7-46 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV7-46-to-partner and partner-to-IGLV7-46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV7-46→partner) and Y-score (partner→IGLV7-46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTATP6P21 →	+0.245	+4.513	<.001	.009	3	2
UCEC	MIR5088 →	+0.908	+5.621	<.001	.004	3	1
SKCM	LINC02862 →	+0.198	+4.215	<.001	.009	3	1
SKCM	SPATA31D5P →	+0.022	+4.381	<.001	.006	3	1
SKCM	RPS3AP17 →	+0.052	+5.199	<.001	.003	3	1
LUAD	LINC00709 →	+0.079	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

IGLV7-46 survival (RNA) · tumor vs normal (RNA) · all IGLV7-46 data types