Across TCGA pan-cancer cohorts, IGLV7-43 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGLV7-43 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGLV7-43 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGLV7-43 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

UCEC, GBM, and LUAD are the cancer types where IGLV7-43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.751	1.000	.042	8	view →
GBM	OS	Median	All	0.294	0.569	.011	4	view →
LUAD	DFS	Median	All	0.901	0.664	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGLV7-43 tumor-vs-normal RNA expression · all IGLV7-43 data types