Across TCGA pan-cancer cohorts, IGLV7-43 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGLV7-43’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGLV7-43 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGLV7-43 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where IGLV7-43 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV7-43 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.928	<.001	8	view →
LUAD	All	II,III,IV	−0.566	<.001	8	view →
PDAC	Female	All	+0.789	.002	3	view →
CCRCC	All	All	+0.474	.009	2	view →
LSCC	All	All	−0.364	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV7-43 RNA expression & survival · all IGLV7-43 data types