Across TCGA patient cohorts, IGLV6-57 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV6-57-associated genes across cancer lineages are RN7SL122P, ATXN3L, and DEFB129. Each is linked with IGLV6-57 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV6-57-to-partner and partner-to-IGLV6-57 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV6-57→partner) and Y-score (partner→IGLV6-57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL122P →	+0.251	+3.163	.003	.004	3	1
SKCM	ATXN3L →	+0.359	+4.254	<.001	.003	3	1
SKCM	DEFB129 →	+0.051	+4.884	<.001	.004	3	1
SKCM	RN7SL517P →	+0.310	+3.875	<.001	.006	3	1
UCEC	FXNP2 →	+0.309	+3.039	<.001	.005	3	1
LUAD	SNORD115-42 →	+0.728	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Exploration

IGLV6-57 survival (RNA) · tumor vs normal (RNA) · all IGLV6-57 data types