Across TCGA pan-cancer cohorts, IGLV5-48 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGLV5-48 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGLV5-48 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV5-48 expression acts as an unfavorable survival marker.

UCEC and LIHC are the cancer types where IGLV5-48 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.106	0.678	.006	12	view →
LIHC	OS	Median	All	0.083	0.783	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IGLV5-48 tumor-vs-normal RNA expression · all IGLV5-48 data types