Across TCGA pan-cancer cohorts, IGLV5-48 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGLV5-48 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV5-48 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV5-48 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where IGLV5-48 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.780	0.523	.001	20	view →
CCRCC	DFS	Median	All	1.000	0.387	.008	19	view →
PDAC	DFS	Tertile	All	0.242	0.549	.014	9	view →
LUAD	DFS	Median	II,III,IV	0.648	0.201	.047	3	view →
GBM	DFS	Tertile	All	0.459	0.213	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV5-48 tumor-vs-normal RNA expression · all IGLV5-48 data types