Across TCGA pan-cancer cohorts, IGLV5-48 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGLV5-48’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGLV5-48 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGLV5-48 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where IGLV5-48 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV5-48 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.812	<.001	11	view →
PDAC	All	All	+1.341	<.001	5	view →
LSCC	Male	All	−0.680	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGLV5-48 RNA expression & survival · all IGLV5-48 data types