Across TCGA pan-cancer cohorts, IGLV5-45 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGLV5-45 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV5-45 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV5-45 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where IGLV5-45 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.567	1.000	.009	16	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	11	view →
LSCC	DFS	Tertile	All	0.877	0.270	.004	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGLV5-45 tumor-vs-normal RNA expression · all IGLV5-45 data types