Across TCGA pan-cancer cohorts, IGLV4-69 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGLV4-69 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGLV4-69 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV4-69 expression acts as an unfavorable survival marker.

LUSC, SKCM, and DLBC are the cancer types where IGLV4-69 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.081	0.818	<.001	12	view →
SKCM	OS	Median	All	0.249	0.781	.011	12	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGLV4-69 tumor-vs-normal RNA expression · all IGLV4-69 data types