Across TCGA patient cohorts, IGLV4-69 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGLV4-69-associated genes across cancer lineages are BNIP3P4, RNA5SP414, and MIR7702. Each is linked with IGLV4-69 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV4-69-to-partner and partner-to-IGLV4-69 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV4-69→partner) and Y-score (partner→IGLV4-69) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P4 →	+0.109	+3.484	<.001	.004	3	1
UCEC	RNA5SP414 →	+0.895	+2.933	<.001	.006	3	1
UCEC	MIR7702 →	+0.415	+5.253	<.001	.001	3	1
UCEC	IGKV2OR2-10 →	+0.116	+3.937	.001	.001	3	1
UCEC	RNVU1-28 →	+0.743	+2.635	.003	.008	3	1
SKCM	RPL35AP →	+0.223	+4.501	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Exploration

IGLV4-69 survival (RNA) · tumor vs normal (RNA) · all IGLV4-69 data types