Across TCGA pan-cancer cohorts, IGLV4-60 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGLV4-60 data layer compared with 19 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IGLV4-60 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV4-60 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where IGLV4-60 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	1.000	0.552	.002	7	view →
HNSC	DFS	Tertile	III,IV	1.000	0.866	.018	6	view →
CCRCC	DFS	Quartile	III,IV	0.233	0.830	.038	3	view →
UCEC	DFS	Tertile	All	0.464	1.000	.049	2	view →
GBM	OS	Median	All	0.283	0.509	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV4-60 tumor-vs-normal RNA expression · all IGLV4-60 data types