Across TCGA patient cohorts, IGLV4-3 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGLV4-3-associated genes across cancer lineages are KRTAP4-16, LINC02522, and SLC25A1P3. Each is linked with IGLV4-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV4-3-to-partner and partner-to-IGLV4-3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV4-3→partner) and Y-score (partner→IGLV4-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	KRTAP4-16 →	+0.076	+4.539	<.001	.008	3	2
UCEC	LINC02522 →	+1.317	+3.030	<.001	.005	3	2
SKCM	SLC25A1P3 →	+0.102	+3.551	<.001	.004	3	2
SKCM	RPA3P2 →	+0.099	+3.669	<.001	.006	3	2
DLBC	SNORD113-3 →	+0.737	+4.874	<.001	.008	3	1
DLBC	SNORD114-24 →	+0.779	+4.874	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

IGLV4-3 survival (RNA) · tumor vs normal (RNA) · all IGLV4-3 data types