IGLV3-31

Across TCGA pan-cancer cohorts, IGLV3-31 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGLV3-31 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV3-31 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV3-31 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, UVM, and CESC are the cancer types where IGLV3-31 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.750	0.538	<.001	118	view →
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
CESC	OS	Tertile	II,III,IV	0.693	0.450	.008	92	view →
BRCA	OS	Tertile	III,IV	0.982	0.884	.020	78	view →
KIRP	DFS	Tertile	III,IV	0.170	0.614	.008	51	view →
LUAD	DFS	Quartile	All	0.752	0.630	.013	27	view →
SKCM	DFS	Tertile	All	0.324	0.187	.004	21	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	18	view →
LAML	DFS	Tertile	All	0.190	0.518	.005	18	view →
TGCT	DFS	Tertile	All	0.961	0.761	.027	12	view →
PAAD	DFS	Tertile	III,IV	0.152	0.821	.045	9	view →
LIHC	OS	Tertile	III,IV	0.094	0.615	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGLV3-31–HNSC (DFS)

Open the HNSC breakdown →