IGLV3-30

Across TCGA pan-cancer cohorts, IGLV3-30 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGLV3-30 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV3-30 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLV3-30 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and BLCA are the cancer types where IGLV3-30 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.597	0.309	<.001	93	view →
BRCA	DFS	Tertile	All	0.941	0.884	.001	78	view →
BLCA	OS	Tertile	All	0.803	0.680	.005	60	view →
OV	OS	Tertile	All	0.677	0.848	.002	36	view →
READ	DFS	Median	III,IV	0.906	0.646	.004	28	view →
MESO	OS	Tertile	III,IV	0.793	0.214	.026	27	view →
LUAD	OS	Tertile	II,III,IV	0.670	0.336	.001	21	view →
PAAD	OS	Tertile	II,III,IV	0.734	0.461	.004	18	view →
CHOL	DFS	Tertile	All	0.852	0.321	.027	18	view →
STAD	OS	Quartile	III,IV	0.207	0.451	.023	12	view →
KIRC	DFS	Tertile	All	0.760	0.883	.018	12	view →
LGG	OS	Tertile	All	0.186	0.531	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGLV3-30–HNSC (OS)

Open the HNSC breakdown →