Across TCGA pan-cancer cohorts, IGLV3-27 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGLV3-27 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGLV3-27 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV3-27 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

UCEC, LUAD, and GBM are the cancer types where IGLV3-27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.886	1.000	.007	14	view →
LUAD	DFS	Quartile	All	0.908	0.601	.036	6	view →
GBM	DFS	Tertile	All	0.496	0.157	.027	2	view →
PDAC	OS	Tertile	All	0.673	0.423	.006	2	view →
CCRCC	DFS	Tertile	All	0.873	0.597	.034	2	view →
HNSC	DFS	Median	III,IV	0.887	1.000	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: IGLV3-27 tumor-vs-normal RNA expression · all IGLV3-27 data types