Across TCGA patient cohorts, IGLV3-22 protein abundance is significantly associated with the RNA expression of many other genes, with 953 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible IGLV3-22-associated genes across cancer lineages are MFNG, CRYBB1, and NCF4. Each is linked with IGLV3-22 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV3-22-to-partner and partner-to-IGLV3-22 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-22→partner) and Y-score (partner→IGLV3-22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MFNG →	+0.500	+1.083	.002	<.001	3	1
CCRCC	CRYBB1 →	+0.495	+1.052	.002	<.001	3	1
CCRCC	NCF4 →	+0.505	+0.881	.006	<.001	3	1
CCRCC	CTSG →	+1.359	+1.165	<.001	<.001	3	1
CCRCC	LGMN →	+0.568	+0.625	.005	.004	3	1
CCRCC	WFDC1 →	+0.642	+0.617	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 953 associations by consensus.

Exploration

IGLV3-22 survival (RNA) · tumor vs normal (RNA) · all IGLV3-22 data types