Across TCGA patient cohorts, IGLV3-22 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGLV3-22-associated genes across cancer lineages are RN7SL196P, SERPINA15P, and MIR6864. Each is linked with IGLV3-22 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV3-22-to-partner and partner-to-IGLV3-22 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-22→partner) and Y-score (partner→IGLV3-22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RN7SL196P →	+0.149	+7.977	<.001	.007	3	2
SKCM	SERPINA15P →	+0.087	+4.624	<.001	.005	3	2
UCEC	MIR6864 →	+1.056	+4.324	<.001	<.001	3	1
UCEC	HNRNPCL3 →	+0.074	+3.608	<.001	.002	3	1
HNSC	MIR512-2 →	+0.363	+7.954	<.001	.008	3	1
SKCM	MIR6090 →	+0.510	+4.159	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Exploration

IGLV3-22 survival (RNA) · tumor vs normal (RNA) · all IGLV3-22 data types