Across TCGA pan-cancer cohorts, IGLV3-21 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGLV3-21 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGLV3-21 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGLV3-21 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, LSCC, and PDAC are the cancer types where IGLV3-21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.399	1.000	.003	44	view →
LSCC	OS	Tertile	II,III,IV	0.655	0.944	.014	11	view →
PDAC	OS	Median	IV	0.381	0.951	.006	9	view →
LUAD	DFS	Quartile	III,IV	0.325	0.991	.006	3	view →
HNSC	DFS	Quartile	III,IV	0.860	0.205	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV3-21 tumor-vs-normal RNA expression · all IGLV3-21 data types