IGLV3-21

RNA expression — cross-omics
Cross-omicsRNA → MUTATIONPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGLV3-21 RNA expression is significantly associated with the mutation status of many other genes, with 9,607 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV3-21-associated genes across cancer lineages are TTN, KRAS, and ACAN. Each is linked with IGLV3-21 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGLV3-21-to-partner and partner-to-IGLV3-21 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-21→partner) and Y-score (partner→IGLV3-21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
KIRPTTN →-1.311-1.281.001.00233
COADKRAS →-0.528-0.828.008.00133
UCECACAN →+1.584+1.328<.001.00133
UCECGPC5 →+2.078+1.587<.001<.00133
UCECCNTN2 →+2.624+2.207<.001<.00133
UCECBRAF →+2.247+1.752.002.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 9,607 associations by consensus.

Exploration