IGLV3-2

Across TCGA pan-cancer cohorts, IGLV3-2 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGLV3-2 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher IGLV3-2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLV3-2 expression acts as an unfavorable survival marker, although some lineages such as OV and BLCA show a favorable association.

OV, THCA, and BLCA are the cancer types where IGLV3-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Tertile	All	0.657	0.312	.027	36	view →
THCA	DFS	Tertile	All	0.352	0.822	<.001	33	view →
BLCA	DFS	Tertile	II,III,IV	0.616	0.317	.010	30	view →
HNSC	DFS	Tertile	All	0.871	0.692	.009	27	view →
COAD	OS	Tertile	IV	0.347	0.668	.020	18	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
LUAD	DFS	Tertile	All	0.824	0.646	.016	12	view →
STAD	OS	Tertile	All	0.193	0.406	.032	12	view →
GBM	DFS	Tertile	All	1.000	0.201	.028	12	view →
THYM	OS	Tertile	All	0.808	0.970	.049	6	view →
BRCA	OS	Tertile	III,IV	0.321	0.566	.044	6	view →
SKCM	DFS	Tertile	All	0.977	0.734	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGLV3-2–OV (OS)

Open the OV breakdown →